Prohibited Substances List

Pursuant to Rule 20(v) of the Rules of Racing and the Irish National Hunt Steeplechase Rules, the Directors of the IHRB hereby publish this schedule of prohibited substances and give notice that each of the following is a Prohibited Substance as defined in the Rules of Racing and the Irish National Hunt Steeplechase Rules:

Substances capable at any time of causing an action or effect, or both an action and effect, within one or more of the following mammalian body systems:

The nervous system, including for example but not limited to:

• anticholinergics
• antidepressants
• antiepileptics
• antihistamines
• anxiolytics
• antiparkinsonians
• antipyretics
• anti-serotonins
• beta agonists
• central analgesics
• central stimulants
• general anaesthetics
• local anaesthetics
• neuroleptics
• non barbiturate hypnotics
• parasympatholytics
• parasympathomimetics
• peripheral analgesics
• psychotropics

The cardiovascular system, including for example but not limited to:

• alpha blockers
• antiarrhythmics
• antihypertensives
• beta agonists
• beta blockers
• cardiac inotropes and chronotropes
• circulatory stimulants
• vasoconstrictors

 

 

The respiratory system, including for example but not limited to:

• antiasthmatics
• antiinflammatories
• antitussives
• beta agonists
• bronchodilators
• clenbuterol
• expectorants
• humidifiers
• mucolytics
• respiratory analeptics
• vasoconstrictors

 

The digestive system, including for example but not limited to:

• anticholinergics
• antidiarrhoeals
• antiemetics
• antigastric acid secretories
• antispasmodics
• choleretics
• emetics
• purgatives
• secretory stimulants
• The urinary system, including for example but not limited to:
• antispasmodics
• diuretics
• inhibitors of urinary secretion
• pH modifiers
• The reproductive system, including for example but not limited to:
• androgens
• oestrogens
• peptide hormones
• progestogens
• prostaglandins
• trophic hormones
• The musculoskeletal system, including for example but not limited to:
• anabolic agents
• corticosteroids
• muscle relaxants
• nonsteroidal antiinflammatories

The blood system, including for example but not limited to:

• anticoagulants
• coagulants
• erythropoietin
• haemostatics

The immune system except for licensed vaccines against infectious agents, including for example but not limited to:

• immunostimulants
• immunosuppressants

 

The endocrine system, including for example but not limited to:

• catecholamines
• glucocorticoids
• insulin
• mineralocorticoids
• pituitary hormones
• thyroid hormones
• trophic hormones

In accordance with Rule 20, the following are Prohibited Substances at all times, including in training:

 

The following substances, including other substances with a similar chemical structure or similar biological effect including but not limited to their metabolites, artefacts and isomers

are prohibited at all times in a Horse as defined in Rule 1.

 

1.1 Non-approved substances

 

Any substance not addressed by any of the subsequent classes of substances, and which has no current approval by any government regulatory authority for veterinary use, or any

substance not universally recognised by veterinary regulatory authorities as valid veterinary therapeutic treatment.

 

1.2 Anabolic agents

(a) anabolic androgenic steroids;

(b) other anabolic agents, including but not limited to selective androgen receptor modulators (SARMs);

(c) beta-2 agonists, unless the substance is prescribed by a veterinarian as a bronchodilator at the appropriate dose.

 

1.3 Peptide hormones, growth factors and related substances (with the exception of oxytocin use in fillies and mares in breeding management or to block oestrus cycling)

(a) erythropoiesis-stimulating agents, including but not limited to erythropoietin (EPO), epoetin alfa, epoetin beta, darbepoetin alfa, and methoxy polyethylene glycol-epoetin beta,

peginesatide

(b) growth hormones and growth hormone releasing factors, insulin-like growth factor-1 (IGF-1), and other growth factors;

(c) synthetic proteins and peptides and synthetic analogues of endogenous proteins and peptides not registered for medical or veterinary use.

 

1.4 Hormone and metabolic modulators

(a) aromatase inhibitors;

(b) selective estrogen receptor modulators (SERMS) and other anti-estrogenic substances;

(c) agents modifying myostatin function, including but not limited to myostatin inhibitors;

(d) insulins;

(e) peroxisome proliferator activated receptor &£948; (PPAR&£948;) agonists, including but not limited to GW 1516;

(f) AMPK activators, including but not limited to AICAR (5-aminoimidazloe-4-carboxamide-1-β-D-ribofuranoside).

 

1.5 Venoms of any species or derivatives thereof

 

1.6 Hypoxia inducible factor (HIF) stabilisers, including but not limited to ITPP (myo-inositol trispyrophosphate), and hypoxia inducible factor (HIF) activators, including but not limited to xenon and argon.

 

1.7 Agents modifying myostatin function, including but not limited to myostatin inhibitors.

 

1.8 Oxygen carriers including but not limited to perfluorochemicals, efaproxiral and modified haemoglobin products.

1. Manipulation of blood and blood components

Withdrawal, manipulation and re-infusion of homologous, heterologous or autologous blood, blood products or blood cells into the circulatory system with the exception of those used for life-saving purposes or as veterinary regenerative therapies for the treatment of musculoskeletal injury or disease.

 

2. Blood Transfusions

Giving a blood transfusion to a horse or allowing or causing a blood transfusion to be given for the purposes of enhancing its performance.

 

3. Genetic and Cellular Manipulation

Modification of the heritable genome at any time of a Horse's life.

Any gene therapy or cellular manipulation in a Horse must not be capable of

• giving the Horse an advantage or disadvantage in a race contrary to the Horse's inherent merits

• being detrimental to the Horse's welfare

 

The IHRB may, at its discretion, allow or disallow racing by Horses or their offspring after such therapy. Any gene therapy for a Horse intended to Race must be fully documented in the Horse's Passport or in such manner as required by the IHRB and shall be reported immediately to the IHRB